Computational Design and Management in Pharmaceuticals

Computational Design and Management in Pharmaceuticals Computational design and management in pharmaceuticals Liu Sui Abstract: Throughout the years since the computer was first developed, the computer has become required and indispensable in modern society. Significant scientific usage of computers has spread throughout all the sciences, including pharmaceutical science. In pharmaceuticals, usage has become an essential tool for the whole drug development process, from initiation of lead searching to finding the best fit, to finding toxicity. This paper will give an overview on how computers are used in the field of computational drug design. The development of computers is a short but exciting history. Looking back at this short history, it perfectly illustrates the intelligence and grittiness of mankind. Since the invention of electronic intelligence, this industry has been growing at an amazing pace. From the technical point of view, computers have changed a huge amount since ENIAC in 1946 to the modern day Intel and ARM architectures permeating our life (Bellis). Computers have changed their role from supercomputer being used for big companies and organizations to the personal computer that exists in just about every household, in one way or another. IT companies have also changed from marketing huge computers to marketing tiny computers to be used in the household, that synchronize with the fast speeds of the modern internet. In 1946, ENIAC was co-operated by the U.S. government and the University of Pennsylvania department of computer science (Goldstine). Features of this first generation of computers were that oper ating instructions were prepared for a specific task, and each machine had its own different mechanical languages. This generation of computers had very limited functionality and slow processing speed. Nonetheless, in less than 60 years, computers have become tools that are used by many different fields of study to enhance their overall value. The rapid development of computer technology has led to a massive expansion of computer-related applications in the pharmaceutical industry. From the local computer system-based assistance, to the inevitable development of network-based assistance, usage of computer networks has become an inevitable trend. Both the computer industry and the pharmaceutical industry influence each other, and the combination of penetration, has and will continue to impact the operating mode of pharmacy. Management and technical decisions made à ¢Ã¢â€š ¬Ã¢â‚¬ ¹Ãƒ ¢Ã¢â€š ¬Ã¢â‚¬ ¹today within the pharmaceutical industry can be combined with the development of computer technology. All pharmacy workers should be aware of this and any future developments. In recent decades, due to the application of computers in pharmaceutical technology, many important achievements have been achieved. Since antiquity, humans have built many tools to physically extend their physical capabilities such as the wheel, the pulley, and the vehicle. On comparison, creating devices to extending mental capability, such as the abacus, calculator, and computer, has also been a great human achievement. Computers are unlike any other tools in which they can replace human labor under pre-programed condition for an indefinite duration. An item only becomes useful for society depending on its function, where computers have many unique features to make them ideal for society: †¢ Computers have incredible calculation ability. †¢ Computers have a huge memory, in order to go through large data sets The CPU and GPU of a computer have the ability to perform billions of complicated math operations per second. In terms of the pharmaceutical technology industry, this huge processing speed is vital for the complex mathematical operations required of this emerging discipline, such as calculating pharmacy finances, calculation and maintaining of pharmaceutical inventory, all the way to calculating drug and other protein formulas, determining the computational drug metabolism and its related pharmacokinetics computing, and pharmaceutical pattern recognition. Many computer-based programs have been developed and continue being improved to fill the huge needs of this industry. In the developmental stage of drug design, to search for drugs that possess the lowest energy in chemical structure can take a very long time, and is hard to do. Many people may question why do we need to calculate the lost energy possibility structure, and this question cannot be answered in one simple sentence. In chemistry, each element is giving a symbol. Molecular formulas use these elemental symbols to show substantive (whether it’s an element or a molecular compound) composition of molecules and their relative molecular weight. Chemical formulas are widely used to present chemicals and chemical reaction. In nature, many drugs have different chemical formula, but at the same time, some compounds that have the exact same molecular formula may not be the same compounds; these compounds are called isomers. Isomers have same chemical formula but different atomic arrangement, and the cause of isomers is the change of order between atoms or groups. One type of isomers is called constitutional isomer. For example, ethanol and methoxymethane both have the chemical formula of C2H6O, but ethanol has an alcohol group, and methoxymethane has an ether function group (figure 1) Figure 1: chemical formula of ethanol and methoxymethane. This is where the software, Gaussian, becomes an invaluabl e part of pharmaceutical chemistry. Gaussian and its related software, Gaussview, are used to search for conformation amongst molecules. Stereoisomers have the molecular atom and group connected to each other in the same order but have different spatial arrangements. Many people may ask why we should care about the spatial arrangements. To answer this question, we need to think about molecules in terms of Classical Physics versus Quantum Physics. In chemistry, each chemical bond contains potential energy. The higher energy level the compounds bonds at, the less stable the compounds becomes. To make a more stable compound is a goal for many chemists because stable compounds have less of a chance to be decomposed, and in nature, many natural products being produced are those in their lowest energy states. The Classical Mechanics approach is mainly used for study of macroscopic objects in slow to stationary motion. Through studying the measureable movements through experiments, chemica ls’ optimal nuclear positions can be found, and the lowest energy state can be found through graphing. However, in chemistry, all chemical bonds are in constant vibration and the ability to study the energy state of electron distribution is more useful for finding the lowest possible energy state. The optimal distribution of electron can be done by quantum mechanics. To think of energy as waves in the ocean, the lowest possible position is actually quite hard to find. It is possible to find some bumps, but these might not be the lowest points. To find the lowest energy points, huge amounts of calculation are needed. At this point, computers become essential. By inputting atomic coordinates, model chemistry and basis set into the software, Gaussian, the software will do the rest of the calculations and provide correct output including atomic coordinates, energy, and a wave function. The wave function can be further interpreted into molecular orbitals, partial charges, electros tatic potential surface, chemical shifts, bond orders, and spin densities. In order to find all these information, a high degree of accuracy is required. However, computers only have a certain amount of accuracy: they can only simulate continuous functions and numbers up to a finite point, leading to an accuracy problem. In general, most chemistry calculations have a certain degree of error that is allowed as long as the relative error in within the sufficient acceptable error range. Theoretically, the precision of calculation by computer is unlimited, but in practicality, most only go as far as a certain amount. Beyond building a drug at its lowest energy state, or find a drug’s real conformation with incredible speed and accuracy, the huge data storage and memory capacity allow for huge amounts of library research. There are huge online drug repositories (both public and private) for researchers and scientists to search for their targeted drug. During the drug development phase, the first part of any research is to screen for lead compounds and modify these lead compounds to make them work on human biology. Because there are literally millions of compounds available to start from, how should one most efficiently find the compound desired? The answer is through computational lead compound search. Computers will input parameters given and search for lead compounds that fit the requirements and list them out with more information. Information retrieval of drug related data is an essential tool in the pharmacist’s tool belt. One example of a great computational research tool used for computational design of drugs is the OpenEye OMEGA software suite. OMEGA is the name of a software product belonging to the OpenEye scientific software suite. OMEGA is a powerful tool for screening toxic chemical groups and providing validation of Lipinski’s rule of 5. OMEGA and vRocs have large libraries that can provide much help throughout the usage of computer-aided drug design. The OpenEye product claims that it â€Å"performs rapid conformational expansion of drug-like molecules, yielding a throughput of tens of thousands of compounds per day per processor (open eye website)†. This is a huge search, and without the modern memory, data storage, and speed of modern computers, this task would be impossible. At the beginning of any computational research, researchers have to get into a specific mindset. First, what disease does this researcher want to work on? Based on the disease selected, what drugs are cur rently on the market? Third, are there any other drugs can be any possible new drug candidates? At this point, researchers can start putting their desired pharmacophora into a computer, and let the computer search the library to suggest any possible candidates for further research. Automated drug screening is a good example of this type of raw processing speed and breadth of data to go through. Extensive automatic pharmacological screening for compounds is the traditional and effective method to find new drugs. The sources of compounds are available for screening on a wide range of values including synthetic compounds, natural extracts, microbial fermentation, and compounds obtained by combinatorial chemistry techniques. There are a large number of these compounds possible, so in order to avoid leakage of data across screenings, screening needs to go through a few dozen general pharmacological screening models. To have the best possible outcomes, usually the combination of computer and robates for a netter system can run a screen quickly, efficiently, and on a large scale of samples. Currently, 10ÃŽ ¼g of a typical compound is a sufficient amount to go through dozens of pharmacological screenings, and as tens of thousands of compounds can be screened per day, t his provides valuable research and development of lead compounds. Within the past few years, even the regular computer is able to store a staggering amount of information. In order to perform the screening methods mentioned above, computers need to have large libraries. However, having a large library is not enough for computer to perform computational research; a certain amount of AI logic is also required. This AI logic ability as implemented through judgment causality analysis is the ability to analyze the proposition being established in order to make the appropriate countermeasures. This logic, or pattern recognition, is nowadays easily implemented by computers. OMEGA is one program can be used for pattern recognition. Drugs are used to cure diseases, but for many drugs, they can be toxic to human at the same time as they are helping us control and cure some diseases. Pattern recognition uses the computer using mathematical methods to study automatic processing techniques and interpretation models. We consider the environment and objects within as a model. With the development of computer technology, it is possible to model extremely complex human information processing. An important form of this type of modeling is the identification process on the environment and the living body object. OMEGA can take as input information on the compounds generated by Gaussian and run through GaussView to filter out toxic compounds. This filter can recognize extremely complex pattern. In this filter, many structures are programed in as toxic groups. Any compounds possessing properties of any of these toxic groups will not pass this filter. Other than toxic groups, this program can also recognize number of hydroge n bond donors (HBD) and hydrogen bond acceptors (HBA). HBD and HBA counts are important for drugs because they are important indication for if a drug candidate can be a production drug or not. Dr. Lipinski is the scientist who first comes up with a so-called â€Å"rule of five.† Linpinski’s rule of five was created in 1997 after Christopher A. Lipinski studied 2245 drugs appear on the World Drug Index that have passed phase II clinical trials. By study these drugs’ structural features he came up with four rules: The molecule weight of these compounds less than 500. The number of HBD is less than 5. The number of HBA is less than 10. Log P is less than 5 (Lipinski) (Lipinski et al) Because of Lipinski’s study, the number of HBA and HBD become one critical point when dealing with finding new drug candidates. The variable â€Å"P† is the lipo-hydro partition coefficient, and Log (P) is used to measure the solubility comparison of a compound’s solubility of octane to water. In order to pass through the body, drugs need to be polar in order to dissolve in the bloodstream. However, a drug should not be too polar, because it needs lipophilicity to pass through cell membrane. OMEGA is able to filter all these individual factors, and provide the end user a spreadsheet with all the information contained. After initial candidates search, it is time to test if the drug has a good binding to the target protein. In the human body, drugs need to bind to target protein thereby either inhibit or excite a series of biological reactions. How well a drug can bind to its target directly affect this drug’s efficiency. This structure-activity relationship is related to a drug’s pharmacokinetics and pharmacodynamics. The chemical structure affects a drug’s properties, and these structures will decide which protein this drug will interact with. A drug should not be too tightly bound to the protein because in this case the drug will be very hard to be metabolized and eliminated through the body, and can cause accumulation in the body, and be toxic. To measure how well a drug can bind to its target, the software VIDA is the best choice. VIDA is a program which can visualize docking results of the drug with the protein in a 3D view. Beyond this entire skillset of detailed programs within pharmaceutical chemistry, it is also nice to have a computer that is easy to use, able to perform automatic work, and bind all these programs together. As more and more modern drug analysis use computer instruments for analysis, so many different analytical instruments and computer connection and so many different instrumentation and automation for online use are not only for the determination of electrochemical, spectroscopic, kinetic equilibrium constant, but they are also used for data processing, statistical analysis and results. This all will allow for drug analysis continue to move forward in a sensitive, accurate and rapid direction. Over the years, computer has been developing rapidly, and at the point, people are not only working on making computer faster. Instead, people trying to put this powerful Programs are designed for people, and by people, reflecting the peoples way of thinking and behavior of action, remember to replace part of the program and will be able to simulate human thinking and activities. Reference Bellis, Mary. The History of the ENIAC Computer. About.com Inventors. About.com, 16 May 2014. Web. 03 June 2014. GOLDSTINE, HERMAN H. Computers at the University of Pennsylvanias Moore School, 1943-1946. Computers at the University of Pennsylvanias Moore School, 1943-1946. PROCEEDINGS OF THE AMERICAN PHILOSOPHICAL SOCIETY, 1992. Web. 04 June 2014. Lipinski, Christopher A. Lead- and Drug-like Compounds: The Rule-of-five Revolution. Lead- and Drug-like Compounds: The Rule-of-five Revolution. Elsevier B.V., Dec. 2004. Web. 04 June 2014. Lipinski, Christopher A., FRANCO Lambardo, Beryl W. Dominy, and Paul J. Feeney. Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings. Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings. Elsevier B.V., Mar. 2001. Web. 04 June 2014. 1

Power-Influence Approach

The power-influence approach in studying leadership examines the influences leaders exert over others, whether these individuals are subordinates, colleagues, or even the leader’s manager. Yuki (2010) writes, â€Å"This research seeks to explain leadership effectiveness in terms of the amount and type of power possessed by a leader and how power is exercised† (p. 14). Power-influence leadership assumes the cause and effect relationship between leaders and followers only flows from management to subordinate (Yuki, 2010, p. 14).For example, a manager instructs his employee to pay an invoice, and the employee does as told, or employees attend an ethics seminar because the executives mandate it. Exercising power-influence can ensure adherence to internal policies like safety, dress codes, and hours of employment. It can also ensure adherence to federal laws like the provisions in the Sarbanes-Oxley Act. The power-influence leadership approach enables a leader to influence t he behaviors and attitudes of followers (Yuki, 2010, p. 14). It is effective in managing and accomplishing tasks as a leader gives instructions that other follow.Power-influence can sway people’s thoughts and opinions, which can be beneficial in terms of innovative ideas and more efficient methods of operations. It is especially effective for those who resist change even if it will lead to progress. The power-influence method of leadership has its drawbacks as well. Some individuals use force and intimidation to accomplish certain objectives. They may use their title or position to pressure others to comply, and even though employees may obey at first, such coercion eventually leads to resistance and the undermining of authority (Alyn, 2009).For example, a manager may tell a direct report that if he does not complete a given stack of work, his quarterly review will reflect it. This is a drastic example of the negative effect of power-influence, but it does well to demonstrate how a manager can use coercion as a source of â€Å"motivation. † Using power to accomplish activities in an organization is a common practice among managers and executives. In fact, prior to 2011, management at Jack in the Box, Inc. depended on the power-influence approach to complete objectives.The organization believed employees required specific instruction, so management influenced subordinates and coworkers through the use of power. It is important to note that few individuals abused this power, but as the nature of the business changed, so did its leadership approach.In 2011, the executives of Jack in the Box worked to change the company’s culture from one of power to one that focused on individual roles, achievements, and support. Management encouraged employees to share ideas, to question and challenge methods of operation, and to take initiative and responsibility for one’s work.The â€Å"you do what I say† mentality was not the attitude the ex ecutives wanted management to express or employees to feel. Instead, the company wanted to nurture leaders to make the organization stronger and more cohesive.Power and one-directional instruction from management to subordinates prevented innovative opportunities and fresher ways of thinking, which ultimately inhibited the company’s possibilities. The new culture placed management and direct reports on more level ground, and the open communication instilled trust and a sense of unity among employees of all levels.The power-influence approach in studying leadership examines the role that power plays in influencing others’ actions, attitudes, and beliefs. Its use can have both positive and negative effects in the workplace, depending on the leader’s intentions.â€Å"Power is viewed as important not only for influencing subordinates, but also for influencing peers, superiors, and people outside the organization, such as clients and suppliers† (Yuki, 2010, p. 14). It is important for leaders to remember that others look to them for instruction, inspiration, and direction. With such power come certain responsibilities and expectations not to abuse it.

Sophocles Antigone An Ancient Greek Writer And...

Antigone Sophocles is an Ancient Greek writer and philosopher, who wrote one of the greatest stories of all tome Antigone. Sophocles is also said to be one of the greatest minds in achievements and times of Sophocles’. Sophocles was born about 496 BC at Colonus in Attica, near Athens and died 406 BC. He lived in the most brilliant intellectual period of Athens. Sophocles, his father, was a wealthy Athenian citizen and gave him a sound education in music, gymnastics, and dancing. He was well known as having a reputation for leaving and esthetic taste. He was well versed in Homer and the Greek lyric poets, and because of his industriousness he was known as the â€Å"Attic Bee’’. Do to his youthful beauty, he was chosen to lead the chorus in†¦show more content†¦Sophocles wrote more than 120 tragedies, only a mear seven have survived. â€Å"Plutarch tells us that there were three periods in Sophocles’ literary developed: imitation of the grand style of Aesc hylus, use of artificial and incisive style, and use of the best style and that which is most expressive of character. It is only from the third period we have examples of.† The seven tragedies that survive are Ajax 447 BC, Antigone 442/441 BC, Oedipus at Colonus 401 BC, and Tracheniae 437-432 BC, Oedipus Rex as a perfect tragedy. Sophocles made many improvements to plays such as adding scene painting and a third actor. He increased the number of the chorus from twelve to fifteen, and reduced the proportion of the play given to the chorus, thereby accelerating the progress of the action; he also made better tragic masks and made many other technical improvements. A grandmaster in the delineation of characters, he is credited with the invention of the heroic maiden, and the ingenuous young man. Antigone is the young princess who pits herself against her uncle, King Creon. She defies his cruel judgement forbidding the burial of her brother Polyneicess who in attempt to invade Th ebes and seize the thrown from his brother Eteocles, slew himself into mortal combat and in turn was slain. Against the pleas of her sister Ismene and her fiancà © Haemon. Antigone goes to her death holding to her defiance and buries Polyneicess. The theme of Antigone had

Assess the functionalist explanations of social inequality

Asses the Functionalist explanations of Social Inequality. (40) Social Inequality refers to any difference between groups or individuals in society which results in one having inferior life chances than the other. Functionalists believe these inequalities are the result of the meritocracy we live in. This is a system based on the idea that social stratification is necessary and desirable for the society. Functionalists argue that inequalities have a purpose; they are functional for society. Functionalism is a structural theory based on the notion that society is based on shared values. This consensus means that society will be in a state of equilibrium and there is harmony, as a result of which there will be social solidarity.†¦show more content†¦There is not a consensus with regard to which are the most important jobs; for e.g. bankers are paid very well but most people would probably argue that nurses are more important to society. Some groups start with more power and status and are therefore are able to ensure they and their childre n get access to the education that will mean they then get a higher status jobs. Life chances are affected by status and wealth and the poor have less access to opportunity to gain access and wealth. Tumin argued that going to universities is not really a sacrifice, although many people in the UK would probably argue it will be as fees go up. The work of the functionalists is not supported by empirical evidence, particularly with regard to the idea that there is a value consensus. Marxism is based on the macro theory which, like functionalism, is concerned with the structure of society. Marxism explains inequalities in societies such as the UK by examining the ways in which the bourgeoisie exploit and oppress the working class or proletariat. Inequalities are a result of the economic arrangements people make to meet their basic needs. Bowles and Gintis used Marxist ideas to explain how the education system reproduced the ideas of the ruling class and legitimated inequalities. They argue students’ experience of schooling is an alienating one. School specifically prepares students for their future as workers in a capitalist system. They argue that school does notShow MoreRelatedAssess the Strengths and Weaknesses of the Functionalist Approach to Society1165 Words   |  5 PagesAssess the strengths and weaknesses of the functionalist approach to society (33 marks) Functionalism is seen as a macro-scale approach to society; it sees society as a whole rather than looking at parts of it. Due to this, functionalism sees society as a body (organic analogy), all the institutions work together to make society. 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The Gucci Guilty Perfume Advertisement - 1079 Words

In this Gucci Guilty perfume advertisement, there are disagreements towards gender roles in advertising, implying how women and men are portrayed. Women are often shown as more feminine, compared to men who are shown as masculine. In the men’s advertisment (ad). the male is put above the female demonstrating his control and power. According to Boundless (2016), in traditional cultural context – males are the dominant gender. The direction of the model s eyes, the man looking directly into the camera, and the woman looking up at the man, can suggest the power dynamics of the genders. Dias (2016), also stated that the way that the man is looking at the camera can suggest that he has the power in the situation and the relationship (Dias,2016). The woman looking up at the man implies that she has less power than him, and that he is what matters to her (Boundless, 2016). The gaze of the female, her posture and her red lips helps to signify affection and goes to show that she is begging for love.The framework in the scene is pitch black, a colour that indicates power and mystery, relating to the control of the male. Harley (2013) stated that the contrasting masculine colour of dark blue in the male’s eyes expresses calmness, tranquillity and guilt, which combines image/text cohesion of the active abstract noun â€Å"guilty† to the facial expression of the male (Harley, 2013). Although in the women’s ad. it is the complete opposite. The male is staring at the women lustfully while theShow MoreRelatedThe Sexual Nature Of Gucci s Fragrance For Men1563 Words   |  7 Pagesshown in our culture today has increased dramatically, in our outfits and in our advertisements. We use the human body, both male and female, to sell products ranging from perfume to hamburgers. It has become more acceptable in our culture to see more rather than leave some of the body to the imagination. This is specifically seen in the magazine advertisement for Gu cci’s fragrance for men, Guilty. This advertisement targets the male audience, specifically the heterosexual male audience. I will useRead MoreStylistic Analysis of the Advertising Slogan1927 Words   |  8 PagesStylistic Analysis Of The Advertising Slogan ---------Perfume Introduction Along with the rapid development of society and economy, advertisements have penetrated into every stratum of the society, becoming the indispensable part of our daily life. Like newspapers, magazines, television, radio, films, telephone directory, art performance, the Internet, and even the human body, advertising makes use of various media to deliver information to the consumerRead MoreThe Advertisements For Gucci s Perfume And Calvin Klein1526 Words   |  7 Pageshave a perfect body shape with beautiful facial features to be considered as attractive. Nowadays, the advertisements are taking advantage of such a social norm to lure consumers to purchase their goods. The advertisements for Gucci’s perfume and Calvin Klein’s cologne are especially good examples to demonstrate such pressure and reflect the consumers’ psychological behavior. The advertisements highlight gender stereotypes through utilizing the impression of opposite sex and incorporate an underly ingRead MoreGucci Brand Management5545 Words   |  23 PagesExecutive Summary This paper examines the brand management of Gucci, as one of today’s most prominent luxury brands. Based on literature it first looks at definitions of luxury and luxury brand equity as an expression of dream value. Then it explores the identity, brand building, brand architecture, brand stretching and strategies Gucci follows in each of its segments. In the light of the latest recession, it looks at the response strategies of the brand and sheds light on the communication challengesRead MoreEssay about Louis Vuitton Moet Hennessy Case6620 Words   |  27 Pagesluxury goods provider with over 1500 stores in 60 different countries employing 56,000 people all over the world. LVMH has 50 sub companies offering products in five different category lines: Wines Spirits, Fashion Leather, Watches Jewelry, Perfumes Cosmetics and Selective Retailing. â€Å"The group has nurtured the best of its brands’ unique expertise and powerful identities to become the world leader in luxury, a position it intends to maintain thanks to a strategy of sustained growthRead MoreStrategic Marketing Management337596 Words   |  1351 PagesIncluded within this are 24-hour television, satellite broadcasting, and a huge upsurge in the numbers of newspapers and ever far more finely targeted magazines. The advertising literacy then follows directly from this in that the sheer number of advertisements to which they have been exposed is higher than ever before. Brand literacy emerges from brands having been an integral part of lifestyles for as long as this generation has been alive, something that was not always the case with older consumers

The Shoe Store Incident Free Essays

This scenario provides a case for gender discrimination. Gender discrimination is illegal under Title VII (Bennett-Alexander Hartman, 2007). In addition, in this scenario I will provide the legal and ethical issues that arise in this case. We will write a custom essay sample on The Shoe Store Incident or any similar topic only for you Order Now Furthermore, this paper will explain what Bob should do in this scenario. Title VII Issues Discrimination comes in all shapes and sizes, and managers have to be careful not to cross the line and do the wrong thing. Companies do not want lawsuits for discrimination or anything else. The storeçâ€" ´ best customer, Imelda, probably did not intend to offend anyone nor did she probably know that she was discriminating against anyone. Many times discrimination is not intended. Customers generally believe they are always right and get what they want. However, in this instance the customer is very wrong. Requesting a female employee over a male employee is a form of discrimination, gender discrimination. Gender discrimination is illegal under Title VII (Bennett-Alexander Hartman, 2007). If Bob asks Tom to step aside and allow Mary to assist Imelda with her purchases, he will be Ã¥ ¦ ¬n violation of Title VII and can be held liable to the employee for gender discrimination. Customer preference is not a legitimate and protected reason to treat otherwise-qualified employees differently based on gender(Bennett-Alexander Hartman, 2007, p. 283). Legally and ethically, Manager Bob cannot swap employees Tom and Mary simply because Imelda wants it. Choice Tthe customer is promising to buy five pairs of shoes if she gets a female employee to help her. This would be a huge purchase for the store, great for the profit margin as well as a large commission for the employee. On the other hand, not providing a female employee may denote a missed sale, Imelda may leave the store. Swapping employees would cheat Tom out of his commission. This would be unethical. Tom deserves his commission; he should not be asked or told to give this up. The Shoe Store has very clear company policies. Company policy does not allow two employees to split the commission (UOPX, 2013, para. 5). As stated previously, having Tom give up his commission would not be fair. Company policy rotates employees to keep commissions as fair and equal as possible (UOPX, 2013, para. 5). Manager Bob need to explain to Imelda as nicely and calmly as possible that he is very sorry, but cannot provide her with a female employee. Bob should promise Imelda that Tom is a very nice man and that she will be in very capable hands; ensure her that Tom knows shoes and will treat her and her feet right. Bob should smile and guarantee her that she will be happy with the service she receives. Bob should apologize for the problem, explain that he contacted his regional manager to see if he could make an exception to company policy this time and was told no, and explain that the company risks a discrimination lawsuit. Finally, tell Imelda that he understands if she chooses to shop elsewhere today and apologize again. Bob should not get into an argument with the customer; it is out of the stores control. Conclusion Knowing the law is important for any manager. When questions arise that cannot be answered easily, ask for help. Title VII does not allow discrimination because of gender, meaning a man cannot be treated differently from a female and visa verse. In this case, all must be treated equally. Company policy will not allow Tom and Mary to split the commission and asking Tom to give up his commission would be illegal. Imelda will need to make her own decision whether to shop at the Shoe Store and allow Tom to assist her or leave for another store or until another day. The company must do what is right and legal. The store must treats its employees properly and do what is legal and ethical. Whereas Imelda may not be happy, the company cannot do anything that may bring a lawsuit against them. How to cite The Shoe Store Incident, Papers

The Penalty of Death free essay sample

He references that in the old days, you were sentenced and it was immediately carried out by hanging or beheading. Although he makes this statement, he also says it’s cruel to leave a prisoner waiting to die. 2) What did you learn from completing this assignment? Did you experience a new understanding of the topic? Did you change your perspective after completing the essay? I changed my perspective on this article after writing in the forum for week three. I realize now that the writer wasn’t pushing for the sentence to be carried out immediately. Instead, his intention was to help people who were sentenced to the death penalty. I was for carrying out the sentence immediately before reading his article. 3) What difficulties did you encounter during the writing or editing phases of the assignment? I enjoy reading over my writing a few times to see where I needed corrections. We will write a custom essay sample on The Penalty of Death or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page In the previous assignment, I wrote about my experiences with writing. I feel that I am a decent writer. 4) What did you enjoy about this assignment? I personally enjoy editing. I do this at my job regularly. Because I am a TSgt, I am responsible for reviewing and editing all of the troop’s annual reports. We call them EPRs. If I had to, I would rather edit than write. 5) Which essay did you chose from the Classic American Arguments section in your textbook? Why did you choose it? I chose â€Å"The Penalty of Death† by H. L. Mencken. I chose this article because I had to do research on the topic in my Public Speaking class. I already had a good working knowledge with this subject. Jeremy Weaver Dr. Nellie Haddad English 102 Feb 26, 2012 9:55 pm The Penalty of Death Critical Evaluation Essay In H. L. Mencken’s The Penalty of Death, the author argues the various reasons of why people are against the death penalty. His argument to them is that it is unjust to keep an inmate on death row for years. Even though the author says the death penalty has an unjust timeframe, it cannot be carried out as quickly as he would hope for because there has to be time for appeals. During the article,  Mencken portrays his argument on the death penalty. Mencken makes quite a few good points during his argument. His usage of â€Å"katharsis† is interesting in the fact that Mencken compares it to the kid placing a tack on the teacher’s chair and then laughing about it. (Mencken 525) Why doesn’t he just come out and say that the kid was yelled at earlier in the day and this is why he placed the tack on the chair. This would make better sense since he uses this term mostly as a replacement for revenge; even though he says that revenge isn’t the right word. He also explains that â€Å"The real objection to capital punishment doesn’t lie against the actual extermination of the condemned, but against our brutal American habit of putting it off for so long. (Mencken 525) This is a solid argument. If the inmate has already been given the opportunity to appeal the conviction and has not succeeded, it is time â€Å"pull the plug. † Why should he or she have to sit and wait for many months or even years? Doing so would make anyone go crazy. We might as well ca ll death row the psyche ward. The tone that Mencken uses in his argument is more personal and opinionated; using what seems to resemble a conversation with himself. Even though he ridicules the American process of the death penalty, ironically, it seems as if he is for it.